Tumor microenvironment response of nano hybrid micelle material is a use of nano technology to different types of materials (such as organic, inorganic, biological, etc.) together, with nuclear shell structure of nano micelles, and then through the tumor microenvironment (such as pH, REDOX potential, enzymes, etc.) response, realize the precise release of drugs or biomolecules of a drug delivery system. This system can improve the targeting, bioavailability and therapeutic efficacy of drugs, reduce the toxic, side effects and drug resistance of drugs, and achieve personalized and precise medical treatment.