Accurately positioned micro and nano drugs are a new type of drug that uses micro or nano technology to wrap or couple drugs on the micro and nano scale carrier, and realizes the precise release and action of drugs at the lesions through specific stimulation factors (such as light, temperature, pH, etc.) or targeted ligands (such as antibodies, peptides, etc.). Accurately positioned micro and nano drugs are highly biocompatible, stable, tunable and functional, and can be used to treat a variety of diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. Precise positioning of micro and nano drugs can improve the targeting and bioavailability of drugs, reduce toxic and side effects, and enhance the therapeutic effect.

A photoresponsive micro-nano drug based on photosensitizer and gold nanorods, which can release chemotherapeutic drugs and produce photothermal effects under the excitation of near-infrared light, thus achieving dual killing of tumor cells. The micro-nanomedicine showed good biosafety, stability and targeting, and demonstrated its excellent photochemical therapeutic efficacy in vitro and in vivo.

A temperature-responsive micro-nano drug based on temperature-sensitive polymer and ferrite nanoparticles can release chemotherapeutic drugs and produce magnetic thermal effect under the heating of alternating magnetic field, thus achieving double killing of tumor cells. The micro-nanodrug had highly efficient drug loading rate, temperature responsiveness, biodegradability and cytotoxicity, and demonstrated its superior magneto-chemotherapeutic efficacy in vitro and in vivo.