Titanium-based functional nanomaterials (titanium-based functional nanomaterials) is a kind of nanoscale material with titanium or its oxides as the main components. It has good biocompatibility, chemical stability, optical performance and surface modifier, and can be used as an efficient acoustic sensitizer or acoustic sensitizer carrier to realize the acoustic dynamic treatment of tumors.

Using titanium dioxide / carbon quantum dots (TiO2 / CQDs) composite nanoparticles as an acoustic sensitizer, to achieve an efficient SDT for breast cancer cells MCF-7. Such composite nanoparticles are well water-soluble, biocompatible and targeted, and can efficiently accumulate within tumor cells. Upon excitation of ultrasound, such composite nanoparticles can produce large amounts of ROS, thereby causing significant oxidative damage and apoptosis to tumor cells.

Using titanium dioxide / polyethylene glycol (TiO2 / PEG) nanotubes as a drug-vehicle platform to achieve combined SDT and chemotherapy for breast cancer cells MCF-7. With a high specific surface area, high loading volume, and high biostability, such nanotubes can effectively encapsulate the anticancer drug DOX. Triered by ultrasound, such nanotubes can release DOX and produce ROS, resulting causing synergistic drug toxicity and oxidative toxicity to tumor cells.

It uses mesoporous titanium dioxide / polyethylene glycol (mTiO2 / PEG) nanoparticles as an acoustic sensitizer to achieve high efficiency SDT of HepG 2. Such nanoparticles with high porosity, high adsorption capacity and high biocompatibility can effectively adsorb the ultrasonic contrast agent thiohexanoic acid (sulfur hexafluoride, SF6). Under ultrasound, such nanoparticles can use their mesoporous structure to produce a cavitation effect, thereby increasing ROS production and mechanical damage to tumor tissue.

参考文献：

Reference Documentation:

[1] Mesoporous TiO2 nanoparticles as a sonosensitizer for sonodynamic therapy of cancer.

[2]TiO2/CQDs composite nanoparticles as a sonosensitizer for sonodynamic therapy of breast cancer。

[3]TiO2/PEG nanotubes as a drug delivery platform for combined sonodynamic and chemotherapy of cancer.

[4]TiO2/PEG nanoparticles as a sonosensitizer for sonodynamic therapy of liver cancer.